If by any chance you can't send a chat message, print a report or list or even export a report or some data on S4, there is a path to solve the issue. 

See the following steps::

1 - Open the Google Chrome > Click on the menu (three dots on the right superior corner of the page;

2 - Select settings;

3 - On the menu on the left, select Privacy and security;

4 - Scroll down and select Site settings ;

5 - scroll down  to Pop-ups and redirects; 

6 - Click on add to add s4 farm link: "s4farm.agriness.com";

The recommendation is that S4 farm is used always on Google Chrome or Mozilla Firefox to avoid incompatibility issues.